A recent analysis of PFAS in the surface waters of SF Bay was conducted to understand the occurrence, fate, and potential risks to ecological and human health. Eleven of 40 PFAS were detected at part per trillions (ppt) concentrations in ambient water collected in 2021 from 22 sites in the Bay. Seven PFAS (PFPeA, PFHxA, PFHpA, PFOA, PFBS, PFHxS, and PFOS), were found in at least 50% of samples. Concentrations of PFAS in the Bay were generally consistent with similar studies globally for surface water. Sustained, multi-matrix monitoring of this important class of contaminants of emerging concern is a high priority for the RMP.